Mental disorders and dementia

Journal title RIVISTA SPERIMENTALE DI FRENIATRIA
Author/s Fabrizio Asioli
Publishing Year 2024 Issue 2024/2
Language Italian Pages 8 P. 9-16 File size 201 KB
DOI 10.3280/RSF2024-002002
DOI is like a bar code for intellectual property: to have more infomation click here

Below, you can see the article first page

If you want to buy this article in PDF format, you can do it, following the instructions to buy download credits

Article preview

FrancoAngeli is member of Publishers International Linking Association, Inc (PILA), a not-for-profit association which run the CrossRef service enabling links to and from online scholarly content.

People with early-life mental disorders are at elevate risk (Relative Risk 4.2) of subsequent dementia and younger dementia onset (5.6 years). Particularly, the association between depression and dementia is discussed, because it is more investigated for the diffusion of depression in general and in elderly population. Findings from these studies on association between mental disorders and dementia suggest that ameliorating mental disorders treatment in early life might reduce risk of cognitive decline in elderly population.

Keywords: Mental disorders, depression, dementia

  1. Ciompi L. Nuovi concetti sulla schizofrenia. In: Faccincani L, Fiorio R, Mignolli G, Tansella M, a cura di. Le psicosi schizofreniche. Dalla ricerca alla pratica. Bologna: Patron; 1984, pp. 195-212.
  2. Mc Gorry PD, Jackson HJ. The ricognition and management of early psychosis. Cambridge: Cambridge University Press, 1999. Tr. It. Riconoscere e affrontare le psicosi all’esordio. Torino: Centro Scientifico Editore, 2001.
  3. Velosa J, Delgado A, Finger E, Berk M, Kapczinski F, de Azevedo Cardoso T. Risk of dementia in bipolar disorders and the interplay of lithium: a systematic review and meta-analysis. Acta Psychiatrica Scandinavica 2020; 14(6): 510-21.
  4. Yang L, Deng YT, Leng Y, Ou YN, Li YZ, Chen SD et al. Depression, Depression treatments, and risk of incident dementia. A prospective cohort study of 354,313 participants. Biological Psychiatry 2023; 93(9): 802-809.
  5. Richmond-Rakerd LS, D’Sousa S, Milne BJ, Caspi A, Moffit TE, Longitudinal association of mental disorders with dementia: 30-year analysis of 1.7 million New Zeeland citiziens. JAMA Psychiatry 2022; 79(4): 333-40.
  6. Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron 2020; 107(2): 234-56.
  7. Rehm J, Hasan OSM, Black SE, Shield KD. Alcohol use and dementia. A systematic scoping review. Alzheimer Research and Therapy 2019; 11(1): 1.
  8. Harvey PD, Rosenthal JB. Cognitive and functional deficits in people with schizophrenia: evidence for accelerated or exaggerated aging? Schizophrenia Research 2018; 196: 14-21.
  9. Holmquist S, Nordström A, Nordström P. The association of depression with subsequent dementia diagnosis: a swedish nationwide cohort study from 1964 to 2016. PLOS Medicine 2020; 17(1): e 1003016.
  11. WHO. Global health estimates 2020 disease burden. Geneva: WHO; 2020.
  12. Rozzini R, Trabucchi M. La depressione nell’anziano. Milano: UTET; 1996.
  13. Brommelhoff JA, Gatz M, Johansson B, McArdle JJ, Fratiglioni L, Pedersen NL. Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins. Psychological Aging 2009; 24(2): 373-84.
  14. Mecocci P, Cherubini A, Senin U. Invecchiamento cerebrale, declino cognitivo, demenza. Un continuum? Roma: Critical Medicine Publishing; 2002.
  15. Bennet S, Grant MM, Aldred S. Oxidative stress in vascular dementia and Alzheimer’s disease: a common pathology. Journal of Alzheimers Diseases 2009; 17(2): 245-57. DOI: 10.3233/JAD-2009-1041
  16. Becker E, Orellana Rios CL, Lachmann C, Rücker G, Bauer J, Boeker M. Anxiety as a risk factor of Alzheimer’s disease and vascular dementia. British Journal of Psychiatry 2018; 213(5): 654-60.
  17. Cai L, Huang J. Schizophrenia and risk of dementia: a meta-analysis study. Neuropsychiatric Disease Treatment 2018; 14: 2047-55. DOI: 10.2147/NDT.S172933
  18. Hendriks S, Ranson JM, Peetom K, Lowida I, Xin XT, de Vugt M et al. Risk factors for young-onset dementia in the UK Biobank. JAMA Neurology 2023, 80(11): 1155-65.
  19. Kohn R, Saxena S, Levav I, Saraceno B. Treatment gap in mental health care. Bulletin World Health Organization 2004; 82(11): 858-66.
  20. Vermeulen-Smit E, Ten Have M, Van Laar M, De Graaf R. Clustering of health risk behaviours and the relationship with mental disorders. Journal of Affective Disorders 2015; 171: 111-19.
  21. Leigh-Hunt N, Bagguley D, Bask K, An overview of systematic reviews on the public health consequences of social isolation and loneliless. Public Health 2017; 152: 157-71.
  22. Kessing LV, Søndegard L, Forman JL, Andersen PK. Antidepressant and Dementia. Journal of Affective Disorders 2009; 117(1-2): 24-9.
  23. Seblova D, Fisher M, Fors S. Does prolonged education causally affect dementia risk when adult socioeconomic status is not altered? A swedish natural experiment in 1.3 million individuals. American Journal of Epidemiology 2021; 190(5): 817-26.

Fabrizio Asioli, Disturbi mentali e demenza in "RIVISTA SPERIMENTALE DI FRENIATRIA" 2/2024, pp 9-16, DOI: 10.3280/RSF2024-002002