The article analyzes One Health as a space of dialogue between heterogeneous disciplinary fields, assuming the concept of risk as a privileged ground for comparison between veterinary and social sciences. Risk is examined in its various forms: as a technical-operational category in veterinary sciences and as a socially produced construct in social sciences. Through this comparison, the article shows how interdisciplinary dialogue takes shape as a situated and asymmetrical process, in which definitions, priorities, and solutions emerge through practices of negotiation and translation. Risk thus becomes an interpretive key to understand how, within the One Health perspective, the cognitive frameworks guiding action and the forms of governance for human, animal, and environmental health are constructed, legitimized, and can be re-oriented.